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KMID : 0368820220610030204
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Journal of the Korean Neuropsychiatr Association
2022 Volume.61 No. 3 p.204 ~ p.213
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Korean Medication Algorithm Project for Bipolar Disorder 2022: Rapid Cycling
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Jeong Jong-Hyun
Bahk Won-Myong
Woo Young-Sup
Yoon Bo-Hyun
Seo Jeong-Seok
Choo Il-Han
Yang Chan-Mo
Kim Won
Lee Jung-Goo
Shim Se-Hoon
Park Sung-Yong
Sohn In-Ki
Kim Moon-Doo
Jung Myung-Hun
Jon Duk-In
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Abstract
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Objectives This study revised the Korean Medication Algorithm Project for Bipolar Disorder2018 for rapid cycling.
Methods Questionnaires to survey the expert opinion of medication for rapid cycling were completed by a review committee consisting of 87 Korean expert psychiatrists. The experts’ opinions ere classified into three categories based on the lowest category in which the confidence interval fell (6.5≤ for first-line, 3.5≤ for second-line, and 3.5> for third-line treatment).
Results The first-line treatments were a combination of mood stabilizers and atypical antipsychotics, atypical antipsychotics monotherapy, or mood stabilizer monotherapy. Furthermore, amood stabilizer with lamotrigine therapy and an atypical antipsychotic with lamotrigine combinations was the first-line treatment for a depressive episode. The first-line medications in all episodeswere valproate, lithium, quetiapine, olanzapine, and aripiprazole. Risperidone was the first-linemedication in manic episodes and mixed states, and lamotrigine was the first-line medication fortreating depressive episodes.
Conclusion Compared to the surveys in 2018, the preference for atypical antipsychotics andlamotrigine has increased, and the modalities as a second-line treatment are more diversified.
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KEYWORD
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Bipolar disorder, Rapid cycling, KMAP-BP 2022
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